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Target
Mitogen-activated protein kinase 3
Ligand
BDBM149408
Substrate
n/a
Meas. Tech.
Omnia Assay
IC50
>1000±n/a nM
Citation
 Haq, N; Niu, D; Petter, RC; Qiao, L; Singh, J; Zhu, Z ERK inhibitors and uses thereof US Patent  US9796700 Publication Date 10/24/2017
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Homo sapiens (Human)
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Inhibitor
Name:
BDBM149408
Synonyms:
US10434101, Compound I-8 | US11096942, Compound I-8 | US8975249, I-8 | US9796700, Compound I-298
Type:
Small organic molecule
Emp. Form.:
C26H28ClN7O3
Mol. Mass.:
521.999
SMILES:
COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Structure:
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