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Target
Acid ceramidase
Ligand
BDBM367184
Substrate
n/a
Meas. Tech.
Fluorescent-based In Vitro Assa
IC50
64.0±7 nM
Citation
 Piomelli, D; Pagliuca, C; Pizzirani, D; Bach, A; Realini, N; De Vivo, M Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent  US10226452 Publication Date 3/12/2019
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM367184
Synonyms:
2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 1
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3
Mol. Mass.:
310.3471
SMILES:
O=C(NCCCCc1ccccc1)n1c2ccccc2oc1=O
Structure:
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