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Target
Tyrosine-protein kinase Yes
Ligand
BDBM50184780
Substrate
n/a
Meas. Tech.
Kinase Screening Assay
IC50
55.0±n/a nM
Citation
 Unciti-Broceta, A; Fraser, C; O. Carragher, N Compounds US Patent  US10294227 Publication Date 5/21/2019
Target
Name:
Tyrosine-protein kinase Yes
Synonyms:
Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes
Type:
Protein
Mol. Mass.:
60801.54
Organism:
Homo sapiens (Human)
Description:
P07947
Residue:
543
Sequence:
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50184780
Synonyms:
CHEMBL3823255 | US10294227, Code 526
Type:
Small organic molecule
Emp. Form.:
C27H40N8O2
Mol. Mass.:
508.6589
SMILES:
COc1cc(ccc1NC(=O)CC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
Structure:
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