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Target
5-hydroxytryptamine receptor 1E
Ligand
BDBM31372
Substrate
Not Available
Meas. Tech.
Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E)
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
2488±n/a nM
Citation
 PubChem, PC Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) PubChem Bioassay (2009)[AID]
Target
Name:
5-hydroxytryptamine receptor 1E
Synonyms:
5-HT-1E | 5-HT1E | 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) | 5-hydroxytryptamine receptor 1E | 5-hydroxytryptamine receptor 1E (5-HT-1E) (S31) | 5-hydroxytryptamine receptor 1E (5-HT-1E) (Serotonin receptor 1E) (5-HT1E) (S31). | 5HT1E_HUMAN | HTR1E | S31 | Serotonin (5-HT) receptor | Serotonin 1e (5-HT1e) receptor | Serotonin Receptor 1E
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41697.80
Organism:
Homo sapiens (Human)
Description:
gi_112822
Residue:
365
Sequence:
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
  
Inhibitor
Name:
BDBM31372
Synonyms:
3-(2-furanyl)-5-(4-nitrophenyl)-2-phenyl-3,4-dihydropyrazole | 3-(furan-2-yl)-5-(4-nitrophenyl)-2-phenyl-3,4-dihydropyrazole | 5-(2-furyl)-3-(4-nitrophenyl)-1-phenyl-2-pyrazoline | 5-(2-furyl)-3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole | MLS000861141 | SMR000459925 | cid_564008
Type:
Small organic molecule
Emp. Form.:
C19H15N3O3
Mol. Mass.:
333.3407
SMILES:
[O-][N+](=O)c1ccc(cc1)C1=NN(C(C1)c1ccco1)c1ccccc1 |t:10|
Structure:
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Substrate
Name:
Not Available
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA