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Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Ligand
BDBM43861
Substrate
n/a
Meas. Tech.
Competition Assay
pH
7.5±0
Temperature
273.15±n/a K
Ki
4.5e+3± 5e+2 nM
Citation
 Peluso, S; de L Ufret, M; O'Reilly, MK; Imperiali, B Neoglycopeptides as inhibitors of oligosaccharyl transferase: insight into negotiating product inhibition. Chem Biol 9:1323-8 (2002) [PubMed]  Article
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Synonyms:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | NLT1 | OST1 | OST1_YEAST | Oligosaccharyl transferase (OT) | Oligosaccharyl transferase subunit alpha
Type:
Protein
Mol. Mass.:
54057.61
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P41543
Residue:
476
Sequence:
MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN
  
Inhibitor
Name:
BDBM43861
Synonyms:
4-[7-[4-[diethyl(methyl)ammonio]butoxy]-9-keto-fluoren-2-yl]oxybutyl-diethyl-methyl-ammonium;iodide | 4-[7-[4-[diethyl(methyl)azaniumyl]butoxy]-9-oxidanylidene-fluoren-2-yl]oxybutyl-diethyl-methyl-azanium;iodide | 4-[7-[4-[diethyl(methyl)azaniumyl]butoxy]-9-oxofluoren-2-yl]oxybutyl-diethyl-methylazanium;iodide | 4-[[7-[4-[diethyl(methyl)ammonio]butoxy]-9-oxo-2-fluorenyl]oxy]butyl-diethyl-methylammonium;iodide | Glycopeptide, 2a | MLS001047162 | SMR000427492 | cid_16681825
Type:
Peptide
Emp. Form.:
C31H48N2O3
Mol. Mass.:
496.7233
SMILES:
CC[N+](C)(CC)CCCCOc1ccc2-c3ccc(OCCCC[N+](C)(CC)CC)cc3C(=O)c2c1
Structure:
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