Reaction Details  Report a problem with these data
Target
Mannose-6-phosphate isomerase
Ligand
BDBM46613
Substrate
n/a
Meas. Tech.
Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
12000±n/a nM
Citation
 PubChem, PC Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2010)[AID]
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM46613
Synonyms:
2-(3-chloranyl-4-fluoranyl-phenyl)-4,6-dinitro-1,2-benzothiazol-3-one | 2-(3-chloro-4-fluoro-phenyl)-4,6-dinitro-1,2-benzothiazol-3-one | 2-(3-chloro-4-fluorophenyl)-4,6-dinitro-1,2-benzothiazol-3-one | MLS-0315768.0001 | cid_8033400
Type:
Small organic molecule
Emp. Form.:
C13H5ClFN3O5S
Mol. Mass.:
369.712
SMILES:
[O-][N+](=O)c1cc([N+]([O-])=O)c2c(c1)sn(-c1ccc(F)c(Cl)c1)c2=O
Structure:
Search PDB for entries with ligand similarity: