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Target
Regulator of G-protein signaling 8
Ligand
BDBM47713
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID]
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47713
Synonyms:
MLS000113446 | N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)-3,4-dimethoxy-N-methyl-benzenesulfonamide | N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-3,4-dimethoxy-N-methylbenzenesulfonamide | N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3,4-dimethoxy-N-methylbenzenesulfonamide | N-(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)-3,4-dimethoxy-N-methyl-benzenesulfonamide | SMR000109344 | cid_1075678
Type:
Small organic molecule
Emp. Form.:
C20H23N3O5S
Mol. Mass.:
417.479
SMILES:
COc1ccc(cc1OC)S(=O)(=O)N(C)c1c(C)n(C)n(-c2ccccc2)c1=O
Structure:
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