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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM48460
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
5203.393456±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID]
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM48460
Synonyms:
MLS000528514 | N-(5-Benzyl-[1,3,4]thiadiazol-2-yl)-2-thiophen-2-yl-acetamide | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-2-(2-thienyl)acetamide | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-2-thiophen-2-ylacetamide | N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]-2-thiophen-2-yl-ethanamide | N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]-2-thiophen-2-ylacetamide | SMR000121089 | cid_900582
Type:
Small organic molecule
Emp. Form.:
C15H13N3OS2
Mol. Mass.:
315.413
SMILES:
O=C(Cc1cccs1)Nc1nnc(Cc2ccccc2)s1
Structure:
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