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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM29617
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
6010±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID]
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM29617
Synonyms:
2-azanylidene-1-(furan-2-ylmethyl)-3-(phenylsulfonyl)dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-(benzenesulfonyl)-1-(2-furanylmethyl)-2-imino-5-dipyrido[1,2-d:3',4'-f]pyrimidinone | 3-(benzenesulfonyl)-1-(furan-2-ylmethyl)-2-iminodipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-Benzenesulfonyl-1-furan-2-ylmethyl-2-imino-1,2-dihydro-1,9,10a-triaza-anthracen-10-one | 3-besyl-1-(2-furfuryl)-2-imino-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | MLS000033902 | SMR000013661 | cid_656318
Type:
Small organic molecule
Emp. Form.:
C22H16N4O4S
Mol. Mass.:
432.452
SMILES:
N=c1c(cc2c(nc3ccccn3c2=O)n1Cc1ccco1)S(=O)(=O)c1ccccc1
Structure:
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