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Target
Ras-related protein Rab-2A
Ligand
BDBM54572
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2009)[AID]
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM54572
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-pentanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pentan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pentan-1-one | KUC103399N | UNM-0000306116 | cid_42628042
Type:
Small organic molecule
Emp. Form.:
C26H32N4O3
Mol. Mass.:
448.5573
SMILES:
COc1ccc(cc1)-c1noc(CCCCC(=O)N2CCN(CC2)c2cc(C)ccc2C)n1
Structure:
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