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Target
Guanyl-specific ribonuclease T1
Ligand
BDBM52921
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1.
IC50
28034±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of tRNA 2'-phosphotransferase (TPT1): fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of RNAse T1. PubChem Bioassay (2009)[AID]
Target
Name:
Guanyl-specific ribonuclease T1
Synonyms:
RNT1_ASPOR | rntA | unnamed protein product
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13952.57
Organism:
Aspergillus oryzae
Description:
gi_83774548
Residue:
130
Sequence:
MMYSKLLTLTTLLLPTALALPSLVERACDYTCGSNCYSSSDVSTAQAAGYQLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT
  
Inhibitor
Name:
BDBM52921
Synonyms:
(5E)-5-(3-ethoxy-4-hydroxy-benzylidene)-1-[2-(4-fluorophenyl)ethyl]barbituric acid | (5E)-5-[(3-ethoxy-4-hydroxyphenyl)methylidene]-1-[2-(4-fluorophenyl)ethyl]-1,3-diazinane-2,4,6-trione | (5E)-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-1-[2-(4-fluorophenyl)ethyl]-1,3-diazinane-2,4,6-trione | 5-[1-(3-Ethoxy-4-hydroxy-phenyl)-meth-(E)-ylidene]-1-[2-(4-fluoro-phenyl)-ethyl]-pyrimidine-2,4,6-trione | MLS000778165 | SMR000414559 | cid_5514790
Type:
Small organic molecule
Emp. Form.:
C21H19FN2O5
Mol. Mass.:
398.3844
SMILES:
CCOc1cc(\C=C2/C(=O)NC(=O)N(CCc3ccc(F)cc3)C2=O)ccc1O
Structure:
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