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Target
Streptokinase A
Ligand
BDBM42059
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID]
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM42059
Synonyms:
MLS000391275 | N-[(Z)-(3-amino-1-isoindolylidene)amino]-4-(4-fluorophenyl)-2-thiazolamine | N-[(Z)-(3-aminoisoindol-1-ylidene)amino]-4-(4-fluorophenyl)-1,3-thiazol-2-amine | N-[(Z)-(3-azanylisoindol-1-ylidene)amino]-4-(4-fluorophenyl)-1,3-thiazol-2-amine | SMR000260312 | [(Z)-(3-aminoisoindol-1-ylidene)amino]-[4-(4-fluorophenyl)thiazol-2-yl]amine | cid_6261459
Type:
Small organic molecule
Emp. Form.:
C17H12FN5S
Mol. Mass.:
337.374
SMILES:
NC1=NC(=NNc2nc(cs2)-c2ccc(F)cc2)c2ccccc12 |w:4.4,t:1|
Structure:
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