Reaction Details  Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM54393
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
<160±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID]
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM54393
Synonyms:
2,2-dimethyl-N-[N'-(5-methyl-1,3-benzoxazol-2-yl)amidino]propionamide | 2,2-dimethyl-N-[N'-(5-methyl-1,3-benzoxazol-2-yl)carbamimidoyl]propanamide | MLS000767476 | N-(2,2-Dimethyl-propionyl)-N'-(5-methyl-benzooxazol-2-yl)-guanidine | N-[amino-[(5-methyl-1,3-benzoxazol-2-yl)imino]methyl]-2,2-dimethylpropanamide | SMR000429824 | cid_3390551
Type:
Small organic molecule
Emp. Form.:
C14H18N4O2
Mol. Mass.:
274.3183
SMILES:
Cc1ccc2oc(N=C(N)NC(=O)C(C)(C)C)nc2c1 |w:7.6|
Structure:
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