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Target
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Ligand
BDBM64781
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1)
IC50
67047±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1) PubChem Bioassay (2010)[AID]
Target
Name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms:
PP-1A | PP1A_HUMAN | PPP1A | PPP1CA | Serine/threonine protein phosphatase PP1-alpha catalytic subunit | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | protein phosphatase 1, catalytic subunit, alpha isoform 3
Type:
PROTEIN
Mol. Mass.:
37510.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197827
Residue:
330
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
  
Inhibitor
Name:
BDBM64781
Synonyms:
4-[[2-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | 4-[[N'-(2,6-dipyrrolidinopyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,5-dien-1-one | 4-[[[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]hydrazo]methylidene]-1-cyclohexa-2,5-dienone | 4-hydroxybenzaldehyde (2,6-di-1-pyrrolidinyl-4-pyrimidinyl)hydrazone | MLS000578760 | SMR000186252 | cid_5340670
Type:
Small organic molecule
Emp. Form.:
C19H24N6O
Mol. Mass.:
352.4335
SMILES:
Oc1ccc(CN=Nc2cc(nc(n2)N2CCCC2)N2CCCC2)cc1 |w:7.7|
Structure:
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