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Target
Caspase-1
Ligand
BDBM76320
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
6590±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID]
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76320
Synonyms:
5-[chloranyl-[1-(4-methylphenyl)-1,2,3,4-tetrazol-5-yl]methyl]-1-(4-methylphenyl)-1,2,3,4-tetrazole | 5-[chloro-[1-(4-methylphenyl)-5-tetrazolyl]methyl]-1-(4-methylphenyl)tetrazole | 5-[chloro-[1-(4-methylphenyl)tetrazol-5-yl]methyl]-1-(4-methylphenyl)tetrazole | 5-[chloro-[1-(p-tolyl)tetrazol-5-yl]methyl]-1-(p-tolyl)tetrazole | MLS000418839 | SMR000236907 | cid_7172585
Type:
Small organic molecule
Emp. Form.:
C17H15ClN8
Mol. Mass.:
366.808
SMILES:
Cc1ccc(cc1)-n1nnnc1C(Cl)c1nnnn1-c1ccc(C)cc1
Structure:
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