Reaction Details  Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM82345
Substrate
n/a
Meas. Tech.
In Vitro Colorimetric Enzyme Assay
IC50
86±n/a nM
Citation
 Hansford, KA; Reid, RC; Clark, CI; Tyndall, JD; Whitehouse, MW; Guthrie, T; McGeary, RP; Schafer, K; Martin, JL; Fairlie, DP D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem 4:181-5 (2003) [PubMed]  Article
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM82345
Synonyms:
hnpsPLA2-IIa Inhibitor, 2p
Type:
Small organic molecule
Emp. Form.:
C31H45NO4
Mol. Mass.:
495.6933
SMILES:
CCCCCCCOc1ccc(C[C@H](CCC(O)=O)NC(=O)CCCCCCc2ccccc2)cc1 |r|
Structure:
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