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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM61384
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
11556±366 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID]
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM61384
Synonyms:
(4-propan-2-ylphenyl) 3-(4-methylpiperazin-1-yl)sulfonylbenzoate | 3-(4-methylpiperazino)sulfonylbenzoic acid p-cumenyl ester | 3-[(4-methyl-1-piperazinyl)sulfonyl]benzoic acid (4-propan-2-ylphenyl) ester | MLS001130011 | SMR000712585 | cid_24817938
Type:
Small organic molecule
Emp. Form.:
C21H26N2O4S
Mol. Mass.:
402.507
SMILES:
CC(C)c1ccc(OC(=O)c2cccc(c2)S(=O)(=O)N2CCN(C)CC2)cc1
Structure:
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