Reaction Details  Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53358
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID]
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53358
Synonyms:
3-(furan-2-carbonyl)-4-hydroxy-2-(4-methylsulfanylphenyl)-1-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)-2H-pyrrol-5-one | 3-(furan-2-ylcarbonyl)-2-(4-methylsulfanylphenyl)-1-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)-4-oxidanyl-2H-pyrrol-5-one | 3-[2-furanyl(oxo)methyl]-4-hydroxy-2-[4-(methylthio)phenyl]-1-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-2H-pyrrol-5-one | 4-(2-furoyl)-3-hydroxy-5-[4-(methylthio)phenyl]-1-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-3-pyrrolin-2-one | MLS001140617 | SMR000650457 | cid_4905842
Type:
Small organic molecule
Emp. Form.:
C19H15N3O4S3
Mol. Mass.:
445.535
SMILES:
CSc1nnc(s1)N1C(C(C(=O)c2ccco2)C(=O)C1=O)c1ccc(SC)cc1
Structure:
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