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Target
P2Y purinoceptor 12
Ligand
BDBM50000878
Substrate
n/a
Meas. Tech.
ChEMBL_89718 (CHEMBL696421)
EC50
>100000±n/a nM
Citation
 Meanwell, NA; Pearce, BC; Roth, HR; Smith, EC; Wedding, DL; Wright, JJ; Buchanan, JO; Baryla, UM; Gamberdella, M; Gillespie, E Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem 35:2672-87 (1992) [PubMed]
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50000878
Synonyms:
7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one | CHEMBL88835
Type:
Small organic molecule
Emp. Form.:
C14H13N7O2
Mol. Mass.:
311.2987
SMILES:
O=c1[nH]c2cc3cc(OCCCc4nnn[nH]4)ccc3nc2[nH]1
Structure:
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