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Target
Cytochrome P450 2D6
Ligand
BDBM50240277
Substrate
n/a
Meas. Tech.
ChEMBL_1667939 (CHEMBL4017827)
IC50
32000±n/a nM
Citation
 Roecker, AJ; Egbertson, M; Jones, KLG; Gomez, R; Kraus, RL; Li, Y; Koser, AJ; Urban, MO; Klein, R; Clements, M; Panigel, J; Daley, C; Wang, J; Finger, EN; Majercak, J; Santarelli, V; Gregan, I; Cato, M; Filzen, T; Jovanovska, A; Wang, YH; Wang, D; Joyce, LA; Sherer, EC; Peng, X; Wang, X; Sun, H; Coleman, PJ; Houghton, AK; Layton, ME Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na Bioorg Med Chem Lett 27:2087-2093 (2017) [PubMed]  Article
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50240277
Synonyms:
CHEMBL4061793
Type:
Small organic molecule
Emp. Form.:
C17H20ClFN4O2S2
Mol. Mass.:
430.948
SMILES:
Fc1cc(NCC23CCCN2CCC3)c(Cl)cc1S(=O)(=O)Nc1nccs1
Structure:
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