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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM189353
Substrate
n/a
Meas. Tech.
ChEBML_1684649
Ki
95±n/a nM
Citation
 ?a?ewska, D; Kurczab, R; Wi?cek, M; Kami?ska, K; Sata?a, G; Jastrz?bska-Wi?sek, M; Partyka, A; Bojarski, AJ; Weso?owska, A; Kie?-Kononowicz, K; Handzlik, J The computer-aided discovery of novel family of the 5-HT Eur J Med Chem 135:117-124 (2017) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM189353
Synonyms:
4-Benzyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine (13)
Type:
Small organic molecule
Emp. Form.:
C15H20N6
Mol. Mass.:
284.3595
SMILES:
CN1CCN(CC1)c1nc(N)nc(Cc2ccccc2)n1
Structure:
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