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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Ligand
BDBM50253251
Substrate
n/a
Meas. Tech.
ChEMBL_1685513 (CHEMBL4035992)
IC50
38000±n/a nM
Citation
 Barlaam, B; Cosulich, S; Fitzek, M; Germain, H; Green, S; Hanson, LL; Harris, CS; Hancox, U; Hudson, K; Lambert-van der Brempt, C; Lamorlette, M; Magnien, F; Ouvry, G; Page, K; Ruston, L; Ward, L; Delouvrié, B Discovery of a novel aminopyrazine series as selective PI3K? inhibitors. Bioorg Med Chem Lett 27:3030-3035 (2017) [PubMed]  Article
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Synonyms:
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha
Type:
PROTEIN
Mol. Mass.:
46228.59
Organism:
Homo sapiens
Description:
ChEMBL_104274
Residue:
406
Sequence:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
  
Inhibitor
Name:
BDBM50253251
Synonyms:
CHEMBL4072637
Type:
Small organic molecule
Emp. Form.:
C17H17N9O
Mol. Mass.:
363.3766
SMILES:
CNC(=O)c1nc(-c2nc(-c3cnc4ccccn34)c(C)nc2N)n(C)n1
Structure:
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