Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50278670
Substrate
n/a
Meas. Tech.
ChEMBL_1719146 (CHEMBL4134146)
EC50
3000±n/a nM
Citation
 Zhang, X; Cai, C; Sui, Z; Macielag, M; Wang, Y; Yan, W; Suckow, A; Hua, H; Bell, A; Haug, P; Clapper, W; Jenkinson, C; Gunnet, J; Leonard, J; Murray, WV Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett 8:947-952 (2017) [PubMed]  Article
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50278670
Synonyms:
CHEMBL4171724
Type:
Small organic molecule
Emp. Form.:
C20H12ClF6NO3S
Mol. Mass.:
495.823
SMILES:
OC(=O)CCc1cc(F)c(OCc2c(nsc2C(F)(F)F)-c2ccc(Cl)c(F)c2)c(F)c1
Structure:
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