Reaction Details  Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50278275
Substrate
n/a
Meas. Tech.
ChEMBL_1719685 (CHEMBL4134685)
IC50
413±n/a nM
Citation
 Duan, YC; Ma, YC; Qin, WP; Ding, LN; Zheng, YC; Zhu, YL; Zhai, XY; Yang, J; Ma, CY; Guan, YY Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment. Eur J Med Chem 140:392-402 (2017) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50278275
Synonyms:
CHEMBL4162637
Type:
Small organic molecule
Emp. Form.:
C23H23N3O
Mol. Mass.:
357.4482
SMILES:
Nc1ccccc1NC(=O)c1ccc(CNC2CC2c2ccccc2)cc1
Structure:
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