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Target
Thromboxane-A synthase
Ligand
BDBM50017896
Substrate
n/a
Meas. Tech.
ChEBML_209935
IC50
1400±n/a nM
Citation
 Martinez, GR; Walker, KA; Hirschfeld, DR; Maloney, PJ; Yang, DS; Rosenkranz, RP [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors. J Med Chem 32:890-7 (1989) [PubMed]
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50017896
Synonyms:
(E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid | 3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid | CHEMBL11662 | CHEMBL542549 | Ozagrel | cid_5282440
Type:
Small organic molecule
Emp. Form.:
C13H12N2O2
Mol. Mass.:
228.2466
SMILES:
OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1
Structure:
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