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Target
Quinolone resistance protein NorA
Ligand
BDBM50368118
Substrate
n/a
Meas. Tech.
ChEMBL_1735976 (CHEMBL4151512)
IC50
4700±n/a nM
Citation
 Felicetti, T; Cannalire, R; Pietrella, D; Latacz, G; Lubelska, A; Manfroni, G; Barreca, ML; Massari, S; Tabarrini, O; Kie?-Kononowicz, K; Schindler, BD; Kaatz, GW; Cecchetti, V; Sabatini, S 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. J Med Chem 61:7827-7848 (2018) [PubMed]  Article
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50368118
Synonyms:
CHEMBL4164737
Type:
Small organic molecule
Emp. Form.:
C25H32N2O3
Mol. Mass.:
408.5332
SMILES:
CCCOc1ccc(cc1)-c1cc(OCCN(CC)CC)c2cc(OC)ccc2n1
Structure:
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