Reaction Details  Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM33959
Substrate
n/a
Meas. Tech.
ChEMBL_1763341 (CHEMBL4198588)
IC50
500±n/a nM
Citation
 de Castro, S; Camarasa, MJ Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy? Eur J Med Chem 150:206-227 (2018) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM33959
Synonyms:
dihydroxy benzoyl naphthyl hydrazone (DHBNH) analogue, 6
Type:
Small organic molecule
Emp. Form.:
C25H20N2O2
Mol. Mass.:
380.4385
SMILES:
COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)-c1ccccc1
Structure:
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