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Target
Isocitrate dehydrogenase [NADP] cytoplasmic
Ligand
BDBM247822
Substrate
n/a
Meas. Tech.
ChEMBL_1764672 (CHEMBL4199919)
IC50
24±n/a nM
Citation
 Zhao, Q; Manning, JR; Sutton, J; Costales, A; Sendzik, M; Shafer, CM; Levell, JR; Liu, G; Caferro, T; Cho, YS; Palermo, M; Chenail, G; Dooley, J; Villalba, B; Farsidjani, A; Chen, J; Dodd, S; Gould, T; Liang, G; Slocum, K; Pu, M; Firestone, B; Growney, J; Heimbach, T; Pagliarini, R Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors. ACS Med Chem Lett 9:746-751 (2018) [PubMed]  Article
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:
Protein
Mol. Mass.:
46661.29
Organism:
Homo sapiens (Human)
Description:
O75874
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM247822
Synonyms:
US10112931, Example 429 | US9434719, 429 | US9688672, Example 429
Type:
Small organic molecule
Emp. Form.:
C19H17ClF2N6O2
Mol. Mass.:
434.827
SMILES:
C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)cc1 |r|
Structure:
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