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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50460093
Substrate
n/a
Meas. Tech.
ChEMBL_1768411 (CHEMBL4220523)
IC50
3.6±n/a nM
Citation
 Fukase, Y; Sato, A; Tomata, Y; Ochida, A; Kono, M; Yonemori, K; Koga, K; Okui, T; Yamasaki, M; Fujitani, Y; Nakagawa, H; Koyama, R; Nakayama, M; Skene, R; Sang, BC; Hoffman, I; Shirai, J; Yamamoto, S Identification of novel quinazolinedione derivatives as ROR?t inverse agonist. Bioorg Med Chem 26:721-736 (2018) [PubMed]  Article
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50460093
Synonyms:
CHEMBL4226313
Type:
Small organic molecule
Emp. Form.:
C25H26ClN5O4
Mol. Mass.:
495.958
SMILES:
CCn1c2ccc(NC(=O)CC(C)CC(=O)Nc3ccc(C#N)c(Cl)c3)cc2c(=O)n(CC)c1=O
Structure:
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