Target
Cathepsin S
Ligand
BDBM50461249
Substrate
n/a
Meas. Tech.
ChEMBL_1771112 (CHEMBL4223224)
IC50
30±n/a nM
Citation
 Nizi, ESferrazza, AFabbrini, DNardi, VAndreini, MGraziani, RGennari, NBresciani, APaonessa, GHarper, S Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins. Bioorg Med Chem Lett 28:1540-1544 (2018) [PubMed]  Article
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50461249
Synonyms:
CHEMBL1215628
Type:
Small organic molecule
Emp. Form.:
C22H28BrN7O
Mol. Mass.:
486.408
SMILES:
CC(C)CN(NC(=O)c1ccc(CN2CCN(C)CC2)cc1)c1nc(ncc1Br)C#N
Structure:
Search PDB for entries with ligand similarity: