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Target
Nuclear receptor ROR-alpha
Ligand
BDBM50466891
Substrate
n/a
Meas. Tech.
ChEMBL_1794588 (CHEMBL4266705)
IC50
>30000±n/a nM
Citation
Schnute, ME; Wennerstål, M; Alley, J; Bengtsson, M; Blinn, JR; Bolten, CW; Braden, T; Bonn, T; Carlsson, B; Caspers, N; Chen, M; Choi, C; Collis, LP; Crouse, K; Färnegårdh, M; Fennell, KF; Fish, S; Flick, AC; Goos-Nilsson, A; Gullberg, H; Harris, PK; Heasley, SE; Hegen, M; Hromockyj, AE; Hu, X; Husman, B; Janosik, T; Jones, P; Kaila, N; Kallin, E; Kauppi, B; Kiefer, JR; Knafels, J; Koehler, K; Kruger, L; Kurumbail, RG; Kyne, RE; Li, W; Löfstedt, J; Long, SA; Menard, CA; Mente, S; Messing, D; Meyers, MJ; Napierata, L; Nöteberg, D; Nuhant, P; Pelc, MJ; Prinsen, MJ; Rhönnstad, P; Backström-Rydin, E; Sandberg, J; Sandström, M; Shah, F; Sjöberg, M; Sundell, A; Taylor, AP; Thorarensen, A; Trujillo, JI; Trzupek, JD; Unwalla, R; Vajdos, FF; Weinberg, RA; Wood, DC; Xing, L; Zamaratski, E; Zapf, CW; Zhao, Y; Wilhelmsson, A; Berstein, G Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem 61:10415-10439 (2018) [PubMed] Article
More Info.:
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG