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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50471648
Substrate
n/a
Meas. Tech.
ChEMBL_2526 (CHEMBL616876)
Ki
2512±n/a nM
Citation
 Bromidge, SM; Dabbs, S; Davies, DT; Duckworth, DM; Forbes, IT; Ham, P; Jones, GE; King, FD; Saunders, DV; Starr, S; Thewlis, KM; Wyman, PA; Blaney, FE; Naylor, CB; Bailey, F; Blackburn, TP; Holland, V; Kennett, GA; Riley, GJ; Wood, MD Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J Med Chem 41:1598-612 (1998) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50471648
Synonyms:
CHEMBL265991
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3OS
Mol. Mass.:
319.809
SMILES:
CSc1cc2CCN(C(=O)Nc3cccnc3)c2cc1Cl
Structure:
Search PDB for entries with ligand similarity: