Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50473509
Substrate
n/a
Meas. Tech.
ChEMBL_1743 (CHEMBL616948)
IC50
58±n/a nM
Citation
 Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem 44:681-93 (2001) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50473509
Synonyms:
CHEMBL2368257
Type:
Small organic molecule
Emp. Form.:
C19H25N3O2
Mol. Mass.:
327.4207
SMILES:
CN(C)[C@H]1C[C@@H](C1)c1c[nH]c2ccc(CC3COC(=O)N3C)cc12 |wU:3.2,wD:5.7,(17.55,-9.96,;18.56,-8.8,;20.07,-9.12,;18.08,-7.35,;16.71,-6.66,;17.39,-5.28,;18.77,-5.97,;16.92,-3.83,;17.81,-2.57,;16.9,-1.33,;15.43,-1.82,;14.1,-1.05,;12.77,-1.83,;12.77,-3.37,;11.43,-4.14,;11.43,-5.68,;10.2,-6.58,;10.67,-8.05,;12.21,-8.05,;13.3,-9.13,;12.68,-6.58,;14.22,-6.58,;14.1,-4.14,;15.45,-3.36,)|
Structure:
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