Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50474421
Substrate
n/a
Meas. Tech.
ChEMBL_3767 (CHEMBL620766)
Ki
0.831764±n/a nM
Citation
 Vermeulen, ES; Schmidt, AW; Sprouse, JS; Wikström, HV; Grol, CJ Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site. J Med Chem 46:5365-74 (2003) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50474421
Synonyms:
CHEMBL609675
Type:
Small organic molecule
Emp. Form.:
C19H26N2
Mol. Mass.:
282.4231
SMILES:
CN(C)[C@H]1CCc2c(C1)cccc2-c1c(C)[nH]c(C)c1C |r,wU:3.2,(6.7,1.36,;5.37,.6,;4.61,1.92,;4.04,-.17,;4.04,-1.72,;2.69,-2.49,;1.35,-1.72,;1.37,-.17,;2.7,.62,;.03,.6,;-1.29,-.17,;-1.29,-1.7,;.03,-2.47,;.05,-4.02,;1.29,-4.91,;2.74,-4.44,;.81,-6.37,;-.72,-6.37,;-1.63,-7.62,;-1.2,-4.91,;-2.66,-4.44,)|
Structure:
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