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Target
Farnesyl diphosphate synthase
Ligand
BDBM25290
Substrate
n/a
Meas. Tech.
ChEMBL_423086 (CHEMBL910471)
IC50
1300±n/a nM
Citation
 Leon, A; Liu, L; Yang, Y; Hudock, MP; Hall, P; Yin, F; Studer, D; Puan, KJ; Morita, CT; Oldfield, E Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. J Med Chem 49:7331-41 (2006) [PubMed]  Article
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
(2E,6E)-farnesyl diphosphate synthase | 2.5.1.10 | FPP synthase | Farnesyl diphosphate synthase | Geranyltranstransferase | ISPA_ECOLI | ispA
Type:
PROTEIN
Mol. Mass.:
32153.72
Organism:
Escherichia coli K-12
Description:
ChEMBL_102603
Residue:
299
Sequence:
MDFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRPFLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGIAGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK
  
Inhibitor
Name:
BDBM25290
Synonyms:
CHEMBL56073 | bisphosphonate, 39 | {1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosphonopropyl}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C14H25NO7P2
Mol. Mass.:
381.2983
SMILES:
CN(CCCCc1ccccc1)CCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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