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Target
Reverse transcriptase
Ligand
BDBM50485013
Substrate
n/a
Meas. Tech.
ChEMBL_817161 (CHEMBL2026077)
IC50
3900±n/a nM
Citation
 Mokale, SN; Lokwani, D; Shinde, DB Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorg Med Chem 20:3119-27 (2012) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50485013
Synonyms:
CHEMBL2023095
Type:
Small organic molecule
Emp. Form.:
C17H14ClN3O
Mol. Mass.:
311.766
SMILES:
CC1=N\C(=C\c2ccc(Cl)cc2)C(=O)N1Cc1ccncc1 |t:1|
Structure:
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