Reaction Details  Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50257840
Substrate
n/a
Meas. Tech.
ChEMBL_902174 (CHEMBL3061572)
IC50
175±n/a nM
Citation
  TBA Med Chem Res 21:100-115 (2012)    Article
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50257840
Synonyms:
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cycloheptylamino)-1-isopropylcyclopentanecarboxamide | CHEMBL494399
Type:
Small organic molecule
Emp. Form.:
C25H34F6N2O
Mol. Mass.:
492.5407
SMILES:
CC(C)[C@@]1(CC[C@H](C1)NC1CCCCCC1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |r|
Structure:
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