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Target
Cathepsin B
Ligand
BDBM50491476
Substrate
n/a
Meas. Tech.
ChEMBL_958842 (CHEMBL2384630)
IC50
>100000±n/a nM
Citation
 Kim, SH; Lee, E; Baek, KH; Kwon, HB; Woo, H; Lee, ES; Kwon, Y; Na, Y Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorg Med Chem Lett 23:3320-4 (2013) [PubMed]  Article
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50491476
Synonyms:
CHEMBL2382056
Type:
Small organic molecule
Emp. Form.:
C17H15BrO4
Mol. Mass.:
363.203
SMILES:
COc1ccc(C(=O)\C=C\c2ccc(OC)c(Br)c2)c(O)c1
Structure:
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