Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50494018
Substrate
n/a
Meas. Tech.
ChEMBL_989827 (CHEMBL2446503)
Kd
12500±n/a nM
Citation
 ?apkauskait?, E; Zubrien?, A; Smirnov, A; Torresan, J; Ki?onait?, M; Kazokait?, J; Gylyt?, J; Michailovien?, V; Jogait?, V; Manakova, E; Gra?ulis, S; Tumkevi?ius, S; Matulis, D Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII. Bioorg Med Chem 21:6937-47 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50494018
Synonyms:
CHEMBL2443197
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4S2
Mol. Mass.:
429.513
SMILES:
Cc1nc(SCC(=O)c2cccc(c2)S(N)(=O)=O)[nH]c(=O)c1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: