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Target
Type-2 angiotensin II receptor
Ligand
BDBM50043440
Substrate
n/a
Meas. Tech.
ChEMBL_35406 (CHEMBL647505)
IC50
6500±n/a nM
Citation
 Dhanoa, DS; Bagley, SW; Chang, RS; Lotti, VJ; Chen, TB; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Patchett, AA; Greenlee, WJ Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. J Med Chem 36:4230-8 (1994) [PubMed]
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50043440
Synonyms:
3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-4-ylmethyl)-2,3-dihydro-indole-1-carbonyl]-benzoic acid | CHEMBL335535
Type:
Small organic molecule
Emp. Form.:
C27H24Cl2N4O3
Mol. Mass.:
523.41
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O
Structure:
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