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Target
Carbonic anhydrase 2
Ligand
BDBM50504305
Substrate
n/a
Meas. Tech.
ChEMBL_1814379 (CHEMBL4313953)
Ki
268±n/a nM
Citation
 Zengin Kurt, B; Sonmez, F; Ozturk, D; Akdemir, A; Angeli, A; Supuran, CT Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies. Eur J Med Chem 183:0 (2019) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50504305
Synonyms:
CHEMBL4524609
Type:
Small organic molecule
Emp. Form.:
C33H36N6O6S
Mol. Mass.:
644.741
SMILES:
CCN(CC)c1ccc(\C=N\Cc2ccc(cc2)S(N)(=O)=O)c(OCc2cn(CCCOc3ccc4ccc(=O)oc4c3)nn2)c1
Structure:
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