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Target
Kallikrein-7
Ligand
BDBM50505098
Substrate
n/a
Meas. Tech.
ChEMBL_1821334 (CHEMBL4320994)
IC50
2800±n/a nM
Citation
 de Souza, AS; Pacheco, BDC; Pinheiro, S; Muri, EMF; Dias, LRS; Lima, CHS; Garrett, R; de Moraes, MBM; de Souza, BEG; Puzer, L 3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7. Bioorg Med Chem Lett 29:1094-1098 (2019) [PubMed]  Article
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM50505098
Synonyms:
CHEMBL4444324
Type:
Small organic molecule
Emp. Form.:
C34H53NO5
Mol. Mass.:
555.7883
SMILES:
CCCCCCCCCCCCCCCCC\C(O)=C1\C(=O)[C@H](Cc2ccccc2)N(C(=O)OC(C)(C)C)C1=O |r|
Structure:
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