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Target
N-alpha-acetyltransferase 40
Ligand
BDBM50506380
Substrate
n/a
Meas. Tech.
ChEMBL_1825680 (CHEMBL4325444)
IC50
>20000±n/a nM
Citation
 Yang, Y; Zhang, R; Li, Z; Mei, L; Wan, S; Ding, H; Chen, Z; Xing, J; Feng, H; Han, J; Jiang, H; Zheng, M; Luo, C; Zhou, B Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. J Med Chem 63:1337-1360 (2020) [PubMed]  Article
Target
Name:
N-alpha-acetyltransferase 40
Synonyms:
2.3.1.257 | N-acetyltransferase 11 | N-alpha-acetyltransferase 40 | N-alpha-acetyltransferase D | NAA40 | NAA40_HUMAN | NAT11 | NatD | PATT1 | Protein acetyltransferase 1 | Synonyms=NAT11 | hNatD
Type:
PROTEIN
Mol. Mass.:
27197.65
Organism:
Homo sapiens
Description:
ChEMBL_119123
Residue:
237
Sequence:
MGRKSSKAKEKKQKRLEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSHHSHAGGHCGGCCH
  
Inhibitor
Name:
BDBM50506380
Synonyms:
CHEMBL4587968
Type:
Small organic molecule
Emp. Form.:
C27H23F4N5O4
Mol. Mass.:
557.4962
SMILES:
Cn1cc(cn1)-c1ccc2c(CC[C@]22NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)c1 |r|
Structure:
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