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Target
Tyrosyl-DNA phosphodiesterase 1
Ligand
BDBM50269845
Substrate
n/a
Meas. Tech.
ChEMBL_1829130 (CHEMBL4329004)
IC50
1000000±n/a nM
Citation
 Zakharenko, AL; Luzina, OA; Sokolov, DN; Kaledin, VI; Nikolin, VP; Popova, NA; Patel, J; Zakharova, OD; Chepanova, AA; Zafar, A; Reynisson, J; Leung, E; Leung, IKH; Volcho, KP; Salakhutdinov, NF; Lavrik, OI Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topote?an on in vivo tumor models. Eur J Med Chem 161:581-593 (2019) [PubMed]  Article
Target
Name:
Tyrosyl-DNA phosphodiesterase 1
Synonyms:
TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Type:
Enzyme
Mol. Mass.:
68430.66
Organism:
Homo sapiens (Human)
Description:
Q9NUW8
Residue:
608
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
  
Inhibitor
Name:
BDBM50269845
Synonyms:
CHEMBL4077630
Type:
Small organic molecule
Emp. Form.:
C26H20O8
Mol. Mass.:
460.4322
SMILES:
Oc1ccc(cc1)[C@H]1[C@@H]([C@@H]([C@H]1c1cc(O)cc(=O)o1)c1ccc(O)cc1)c1cc(O)cc(=O)o1 |r|
Structure:
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