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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Ligand
BDBM227594
Substrate
n/a
Meas. Tech.
ChEMBL_1833040 (CHEMBL4333048)
IC50
760±n/a nM
Citation
 Lee, D; Pagire, HS; Pagire, SH; Bae, EJ; Dighe, M; Kim, M; Lee, KM; Jang, YK; Jaladi, AK; Jung, KY; Yoo, EK; Gim, HE; Lee, S; Choi, WI; Chi, YI; Song, JS; Bae, MA; Jeon, YH; Lee, GH; Liu, KH; Lee, T; Park, S; Jeon, JH; Lee, IK; Ahn, JH Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem 62:575-588 (2019) [PubMed]  Article
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Synonyms:
PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4
Type:
Enzyme
Mol. Mass.:
46469.71
Organism:
Homo sapiens (Human)
Description:
Q16654
Residue:
411
Sequence:
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
  
Inhibitor
Name:
BDBM227594
Synonyms:
PS10
Type:
Small organic molecule
Emp. Form.:
C14H13NO6S
Mol. Mass.:
323.321
SMILES:
Oc1ccc(c(O)c1)S(=O)(=O)N1Cc2cc(O)cc(O)c2C1
Structure:
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