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Target
Reverse transcriptase
Ligand
BDBM50508779
Substrate
n/a
Meas. Tech.
ChEMBL_1834348 (CHEMBL4334356)
IC50
18±n/a nM
Citation
 Pribut, N; Basson, AE; van Otterlo, WAL; Liotta, DC; Pelly, SC Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Med Chem Lett 10:196-202 (2019) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50508779
Synonyms:
CHEMBL4450185
Type:
Small organic molecule
Emp. Form.:
C16H12ClN3O2
Mol. Mass.:
313.738
SMILES:
CCn1c2c(Oc3cc(Cl)cc(c3)C#N)cccc2[nH]c1=O
Structure:
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