Reaction Details  Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50004566
Substrate
n/a
Meas. Tech.
ChEMBL_29303 (CHEMBL640364)
Ki
21±n/a nM
Citation
 Kim, YC; de Zwart, M; Chang, L; Moro, S; von Frijtag Drabbe Künzel, JK; Melman, N; IJzerman, AP; Jacobson, KA Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J Med Chem 41:2835-45 (1998) [PubMed]  Article
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50004566
Synonyms:
9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine | 9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943) | 9-Chloro-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943) | 9-chloro-2-(2-furanyl)-1,2,4-triazolo[1.5-c]quinazolin-5-amine | 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine | CGS-15943 | CHEMBL16687 | CHEMBL268431 | Nonnucleoside analog, 4
Type:
Small organic molecule
Emp. Form.:
C13H8ClN5O
Mol. Mass.:
285.689
SMILES:
Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: