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Target
NT-3 growth factor receptor
Ligand
BDBM50513631
Substrate
n/a
Meas. Tech.
ChEMBL_1853740 (CHEMBL4354364)
IC50
693±n/a nM
Citation
 Cui, S; Wang, Y; Wang, Y; Tang, X; Ren, X; Zhang, L; Xu, Y; Zhang, Z; Zhang, ZM; Lu, X; Ding, K Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur J Med Chem 179:470-482 (2019) [PubMed]  Article
Target
Name:
NT-3 growth factor receptor
Synonyms:
GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C)
Type:
Enzyme
Mol. Mass.:
94428.15
Organism:
Homo sapiens (Human)
Description:
Q16288
Residue:
839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
  
Inhibitor
Name:
BDBM50513631
Synonyms:
CHEMBL4438225
Type:
Small organic molecule
Emp. Form.:
C29H27F3N6O2
Mol. Mass.:
548.5589
SMILES:
COc1c(cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)C#Cc1cnc2cnccn12
Structure:
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