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Target
Polyamine deacetylase HDAC10
Ligand
BDBM50398716
Substrate
n/a
Meas. Tech.
ChEMBL_1884823 (CHEMBL4386405)
IC50
501±n/a nM
Citation
 Géraldy, M; Morgen, M; Sehr, P; Steimbach, RR; Moi, D; Ridinger, J; Oehme, I; Witt, O; Malz, M; Nogueira, MS; Koch, O; Gunkel, N; Miller, AK Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem 62:4426-4443 (2019) [PubMed]  Article
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
71431.89
Organism:
Homo sapiens (Human)
Description:
Q969S8
Residue:
669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
  
Inhibitor
Name:
BDBM50398716
Synonyms:
CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g
Type:
Small organic molecule
Emp. Form.:
C19H23N3O3
Mol. Mass.:
341.4042
SMILES:
CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1
Structure:
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