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Target
Neuronal acetylcholine receptor subunit alpha-9
Ligand
BDBM50077117
Substrate
n/a
Meas. Tech.
ChEMBL_142765 (CHEMBL750486)
IC50
110±n/a nM
Citation
 Vernier, JM; El-Abdellaoui, H; Holsenback, H; Cosford, ND; Bleicher, L; Barker, G; Bontempi, B; Chavez-Noriega, L; Menzaghi, F; Rao, TS; Reid, R; Sacaan, AI; Suto, C; Washburn, M; Lloyd, GK; McDonald, IA 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem 42:1684-6 (1999) [PubMed]  Article
Target
Name:
Neuronal acetylcholine receptor subunit alpha-9
Synonyms:
ACHA9_RAT | Acra9 | Cholinergic, Nicotinic Muscle | Chrna9 | NACHR alpha 9 | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54522.69
Organism:
RAT
Description:
Cholinergic, Nicotinic Muscle 0 RAT::P43144
Residue:
479
Sequence:
MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
  
Inhibitor
Name:
BDBM50077117
Synonyms:
4-[2-(1-Methyl-pyrrolidin-2-yl)-ethylsulfanyl]-phenol | CHEMBL47850
Type:
Small organic molecule
Emp. Form.:
C13H19NOS
Mol. Mass.:
237.361
SMILES:
CN1CCCC1CCSc1ccc(O)cc1
Structure:
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